The current study investigated the effect of flavonoid rich fraction of Helicteres isora (Sterculiaceae) fruit for antidiabetic activity. Streptozotocin (STZ) induced Type II diabetic model was used for induction of diabetes mellitus in Sprague Dawley rats. The flavonoid rich fraction of Helicteres isora fruit was administered orally (100, 200, 400 mg/kg b.w) and metformin was used as the standard reference drug. The effect of flavonoid rich fraction of Helicteres isora fruit on body weight, serum glucose, serum cholesterol, serum HDL, serum albumin, serum triglycerides, serum creatinine, serum alkanine phosphatase, serum total protein were estimated in streptozotocin (STZ) induced diabetic rats. A significant decrease in plasma glucose level, serum creatinine level were observed on treatment with 400 mg/kg b.w. of Helicteres isora fruit extract and metformin for 1 week responsible for antidiabetic activity. The ability of the flavonoid rich fraction Helicteres isora (400 mg/kg b.w.) to reduce lipid profile especially triglycerides and low density lipoproteins, cholesterol were represented a protective mechanism against the development of atherosclerosis and atherosclerotic cardiovascular disease complications especially in type-II diabetes mellitus.
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